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Signaling and biological effects of glucagon-like peptide 1 on the differentiation of mesenchymal stem cells from human bone marrow
Donors (10 females, 14 males) were on average 48 years old (range 1961) with a BMI of 28 (range 2137)
Conversely, Ex-4, as a GLP-1 receptor agonist (GLP-1RA), demonstrates potent inhibitory effects on these tumor cells [96]
However, sustained HIF-1 activation in the context of neurodegeneration may exacerbate inflammation and promote A production, thereby worsening synaptic dysfunction and neuronal damage (Zhang et al., 2007)